Differentiation of Cancer Cells

Well-differentiated:

The cancer cells look and act more like regular, healthy cells. They grow slower and are easier to identify as cancer cells. ​Tumors with well-differentiated cells often have a better prognosis. These cancers tend to be less aggressive, grow slower, and are more localized. They might respond better to treatments. Patients with well-differentiated cancers may have a higher chance of successful treatment and a better long-term outlook.

Moderately differentiated:

These cancer cells are somewhat different from normal cells. They might show some unusual features but aren't as abnormal as poorly differentiated cells. Cancers falling into this category can have varying prognoses. They're somewhat abnormal but not as aggressive as poorly differentiated ones. Treatment decisions might depend on other factors like the cancer's stage, location, and the overall health.

Poorly differentiated

(or undifferentiated):

These cancer cells are very abnormal and look very different from healthy cells. They grow quickly and can be harder to identify as cancer cells because they've changed so much. These cancers tend to be more aggressive, grow faster, and are more likely to spread. They often have a poorer prognosis and may be harder to treat. Treatment for poorly differentiated cancers may involve more aggressive therapies and often need a combination of treatments in order to control the disease.